Spanning over four decades, the Panel Study of Income Dynamics (PSID) is the world’s longest-running household panel survey. The resulting data archive presents research opportunities for breakthroughs in understanding the connections between economic status, health and well-being across generations and over the life course. The long panel, genealogical design, and broad content of the data represent an unique opportunity for a multi-perspective study of life course evolution and change within families over multiple generations. This paper provides an overview of the PSID and its supplemental studies, the Disability and Use of Time Supplement, the Child Development Supplement, and the Transition into Adulthood study, and describes features and recent enhancements that have increased the potential of the archive for studying life course development.